IUPAC name : Isoleucine
Other names :2-Amino-3-methylpentanoic acid
Essential - Proteogenic - Glycogenic and Ketogenic
Non-Polar, Hydrophobic - Aliphatic
One of the 3 major Branched-Chain Amino Acids (BCAA), all of which are involved with muscle strength, endurance, and muscle stamina.
Muscle tissue uses Isoleucine as an energy source.
Required in the formation of hemoglobin.
BCAA levels are significantly decreased by insulin.
High dietary sugar or glucose intake causes release of insulin, which, in turn, causes a drop in BCAA levels. Therefore, right before exercise, it is not wise to ingest foods high in glucose or other sugars, as the BCAA's, including Isoleucine will not be readily available to muscles.
Isoleucine Deficiency Seen In:
Chronic Fatigue Syndrome (Note: Deficiencies in BCAA in CFS, GWS, FM are associated with muscle weakness, fatigue, and post-exertional exhaustion).
Isoleucine Excess Seen In:
Diabetes Mellitus with ketotic hypoglycemia